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A APM apóia e promove diversos programas culturais e sociais. Esta estreita relação entre a associação e a arte vem desde os tempos de sua fundação, quando artistas plásticos freqüentavam reuniões na entidade. Foi assim que surgiu a Pinacoteca Ernesto Mendes da Associação Paulista de Medicina. Exposições de arte, programas musicais que vão da MPB ao jazz, passando pela música erudita, cinema, escola de artes são algumas das atividades oferecidas.

São programas que multiplicam o conhecimento, alguns são acompanhados de palestras, como o Cine-Debate, o Conheça a Ópera, Clube do Jazz e as palestras de História da Arte. Para o médico que toca algum instrumento ou faz parte de alguma banda, a entidade realiza, uma vez por ano, o Festival do Médico Músico, onde os profissionais mostram seus dons musicais aos colegas. Além disso, busca ainda firmar parcerias para que o associado tenha descontos em peças teatrais e parques de diversões de São Paulo.

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